Children's Cancer Group, China

This study tests whether giving intensive chemotherapy along with early and strong doses of the targeted drug rituximab can improve event-free survival and overall survival in children and adolescents with aggressive B-cell non-Hodgkin lymphoma. About 87 participants will receive…

This study compares two different ways of giving methotrexate (a chemotherapy drug) to children and teens newly diagnosed with T-cell lymphoblastic lymphoma, a rare cancer of the immune system. About 200 participants will be randomly assigned to one of two treatment plans to see …

This study tests a new treatment for children, teens, and young adults (ages 2 to 34) newly diagnosed with classical Hodgkin lymphoma. The drug brentuximab vedotin replaces two older drugs to see if it can shrink tumors faster and more completely, so fewer patients need radiation…