STAGE II PANCREATIC CANCER AJCC V8

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed or has spread. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab), alongside standard chemotherapy. The goal is to see i…

This early-phase study tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The treatment pairs a targeted chemotherapy with immunotherapy drugs and standard chemo to see if it's safe and what dose works best. About 74 a…

This early-phase trial is testing whether combining the targeted drug olaparib, the immunotherapy durvalumab, and radiation therapy is safe for people with locally advanced pancreatic cancer that cannot be surgically removed. The study enrolls 18 participants who have already rec…

This early-phase study tests whether adding losartan (a blood pressure medicine) to a shorter, higher-dose radiation treatment can help people with pancreatic cancer that is hard to remove surgically. The main goal is to check for side effects and find the safest dose. About 22 a…

This phase II trial tests whether a combination of lenvatinib (a targeted drug) and pembrolizumab (an immunotherapy) can help keep advanced pancreatic cancer from progressing. The study includes 28 adults whose cancer has not spread further after initial treatment. Participants r…

This early-stage trial aimed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancer, or melanoma that has spread or cannot be removed. STIL101 is made from a patient's own immune cells taken from their tumor, …

This early-phase trial tests two drugs together in 15 people with advanced pancreatic cancer. One drug, calaspargase pegol-mknl, lowers a nutrient that cancer cells need to grow. The other, cobimetinib, blocks a protein that helps cancer cells survive. The goal is to find a safe …

This study tests a new method called sonoporation, which uses ultrasound and tiny gas bubbles to help chemotherapy drugs get into cancer cells more effectively. The trial includes 120 adults with advanced or hard-to-remove pancreatic cancer who are already receiving standard chem…