REFRACTORY CANCER
Clinical trials for REFRACTORY CANCER explained in plain language.
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New hope for kids with resistant tumors: drug combo enters safety trial
Disease control OngoingThis early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…
Matched conditions: REFRACTORY CANCER
Phase: PHASE1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Experimental 'T cell Engager' takes on Hard-to-Treat cancers
Disease control OngoingThis early-phase trial is testing a new drug called IMA401, which helps the body's immune T cells attack cancer cells that have certain markers (MAGE-A4 or MAGE-A8). The study includes about 95 adults with advanced solid tumors that have come back or not responded to other treatm…
Matched conditions: REFRACTORY CANCER
Phase: PHASE1 • Sponsor: Immatics Biotechnologies GmbH • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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New drug shows promise for stubborn cancers
Disease control OngoingThis study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…
Matched conditions: REFRACTORY CANCER
Phase: PHASE2 • Sponsor: Actuate Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Lab tests aim to tailor cancer treatments for patients who've run out of options
Knowledge-focused OngoingThis study tests whether doctors can quickly recommend personalized cancer treatments for adults whose cancers have returned or stopped responding to standard therapy. Researchers will take a sample of the tumor, test it against many drugs in the lab, and also analyze its genes. …
Matched conditions: REFRACTORY CANCER
Phase: NA • Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC