RECURRENT WHO GRADE 2 GLIOMA

This study is testing a drug called tipifarnib in children and young adults whose advanced cancers have a specific genetic change in a gene called HRAS. The goal is to see if the drug can shrink tumors and control the disease. Participants take the drug as a pill or through a fee…

This study is for children and young adults whose low-grade brain tumor has come back or stopped responding to treatment. It aims to find out if combining two drugs, selumetinib and vinblastine, works better than using selumetinib alone to control the tumor and prevent it from gr…

This study is testing a targeted drug called selpercatinib in children and young adults with advanced or returning cancers that have specific changes in a gene called RET. The goal is to see if the drug can shrink tumors and control the cancer's growth. Participants take the drug…

This early-stage study is testing a new drug combination for adults whose aggressive brain cancer (glioblastoma) has returned. Researchers want to find the safest and most effective dose of an experimental drug called triapine when given with the standard chemotherapy temozolomid…

This study is testing a drug called ivosidenib in children and young adults (ages 1-21) whose cancers have returned or not responded to standard treatments. The drug is given as a daily pill and is designed to specifically block cancer growth in tumors that have a particular gene…