RECURRENT MALIGNANT NEOPLASM

This study is testing whether choosing cancer drugs based on the unique genetic changes found in a patient's tumor is more effective at controlling the disease than standard treatment. It involves over 1,300 people with metastatic cancer, meaning cancer that has spread. Patients …

This early-stage trial aims to find safe doses and understand side effects of several drug combinations for patients with advanced cancers that haven't responded to standard treatments. The study involves 155 participants with various advanced or metastatic cancers and some rare …

This study is testing an oral medication called talazoparib for people with advanced cancers that have spread, returned, or stopped responding to standard treatments. It is specifically for patients whose cancers have certain genetic changes in the BRCA pathway (like BRCA1, BRCA2…

This study is testing whether combining physical activity with a short course of the steroid dexamethasone can reduce severe fatigue in people with advanced cancer. It enrolled 90 participants to compare a high-dose steroid week with a low-dose steroid week, both alongside a 4-we…

This study aims to see if a common stimulant medication (methylphenidate) combined with a guided exercise program can reduce severe, cancer-related fatigue. It involves 212 patients with advanced cancer who are receiving a specific type of immunotherapy (anti-PD1) and are struggl…

This study aims to find the best way to calm severe, distressing agitation (delirium) in hospitalized patients with advanced cancer who are receiving comfort-focused care. It compares four different drug strategies for patients whose initial low-dose medication isn't working. The…

This study is testing different medication strategies to quickly calm severe, distressing agitation (delirium) in hospitalized patients with advanced cancer. It involves 70 patients whose initial low-dose medication hasn't worked. Researchers are comparing three approaches: incre…

This study aims to understand how common and severe financial distress is for people with advanced cancer. Researchers are asking 141 patients to complete short surveys about their financial situation, symptoms, and quality of life. The goal is to learn how the high cost of cance…