PERTUSSIS

This trial evaluates a new five-component vaccine (Tdcp) designed to protect against diphtheria, tetanus, and pertussis (whooping cough). It includes about 1,820 participants aged 7 and older, who receive either the experimental vaccine or a control vaccine. The study measures ho…

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This study tested a booster dose of the DTaP vaccine (BK1301) in 446 adolescents aged 11-12 who had already received the standard childhood series. The goal was to confirm the vaccine boosts immunity against diphtheria, tetanus, and pertussis (whooping cough) safely. Results show…

This early-stage study tested a new whooping cough vaccine given as a nasal spray. 48 healthy adult men received either the vaccine or a placebo to check safety and immune response. The goal is to develop a single-dose vaccine that can protect infants from birth, before they get …

This early-stage trial is testing an experimental vaccine designed to protect people aged 6 and older against diphtheria, tetanus, and pertussis (whooping cough). The study will enroll 180 participants to check the vaccine's safety and how well it triggers an immune response. Som…

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This completed study looked at 200 women and their infants to understand how the whooping cough vaccine given during pregnancy affects the baby's immune protection. Researchers measured antibody levels in mothers and in umbilical cord blood at birth, as well as in infants after t…