NEOPLASMS BY SITE

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who cannot have surgery or radiation. Researchers…

This program gives patients with advanced ROS1-positive non-small cell lung cancer access to taletrectinib, an experimental drug, when no approved treatments or other clinical trials are available. Participants must be 18 or older, have a confirmed ROS1 gene fusion, and adequate …

This study tests a new drug called savolitinib against a standard treatment (sunitinib) in 60 people with a specific type of advanced kidney cancer (papillary renal cell carcinoma) driven by a MET gene change. The goal is to see if savolitinib can slow cancer growth and improve s…

This early-stage study tests an experimental pill, ATV-1601, for people with advanced solid tumors or certain breast cancers that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. About 134 ad…

This study compares two treatments for early-stage throat cancer: robotic surgery (TORS) or radiation therapy (IMRT). It looks at which one leads to better swallowing function and overall quality of life. About 138 adults with HPV-related throat cancer are taking part. The goal i…

This study looks at whether educating doctors in small and mid-sized city hospitals about official guidelines can improve how they test and treat patients with advanced lung cancer. About 1000 patients with metastatic non-small cell lung cancer will have their medical records rev…

This study is watching how a robotic tool called the Ion Endoluminal System performs when doctors use it to take samples from lung spots or guide treatment. About 1,300 adults who need a lung biopsy or localization will take part. The goal is to see how often the system correctly…