HSCT

This study aims to see if using a lower dose of a powerful drug called cyclophosphamide after a stem cell transplant is just as effective as the standard higher dose. It will involve 180 adults with blood cancers who are receiving a transplant from a half-matched donor. The main …

This study is testing whether adding the drug Gecacitinib before, during, and after a stem cell transplant can help people with myelofibrosis, a serious bone marrow disease. The main goal is to see if the drug helps patients survive the first year after transplant without their d…

This early-stage study is testing an experimental drug called Gecacitinib for people with chronic graft-versus-host disease (cGVHD) that doesn't improve with standard steroid treatment. The trial will first find a safe dose and then see if the drug helps control the disease and i…

This study is testing a new drug called zuberitamab to see if it can safely and effectively treat early signs of Epstein-Barr virus (EBV) infection in adults who have recently received a donor stem cell transplant. The goal is to prevent the virus from causing a serious, often fa…

This study is testing a gentler chemotherapy drug called treosulfan before a stem cell transplant for patients with Nijmegen breakage syndrome, a rare genetic disorder. The goal is to see if using lower doses can reduce severe side effects and transplant-related risks while still…

This study is testing a combination of two drugs, olverembatinib and inotuzumab ozogamicin, for adults with a specific type of acute leukemia (Ph+ ALL). The goal is to see if this treatment can clear very low levels of remaining cancer cells after initial chemotherapy, which is a…

This study is testing whether a drug called luspatercept can help patients with blood cancers recover from anemia (low red blood cells) after a stem cell transplant. Researchers want to see if the drug reduces the need for blood transfusions and helps the new stem cells work bett…

This study tests whether using precise, high-dose radiation on tumors outside the bone marrow before a stem cell transplant improves outcomes for adults with blood cancers. It aims to see if this approach helps patients live longer and reduces the chance of the cancer returning. …

This study is testing a new, less toxic combination of chemotherapy drugs (thiotepa and melphalan) for patients with an aggressive form of chronic myeloid leukemia (CML) called blast phase. The goal is to better control the disease and improve survival by preparing patients for a…

This study aims to understand why and how heart problems develop in patients receiving stem cell transplants for blood cancers. Researchers will follow 400 transplant patients for one year, using heart scans, blood tests, and health tracking to identify early warning signs of hea…

This study aims to understand how children's thinking skills, memory, and physical health change during the first year after a life-saving stem cell transplant. Researchers will follow 100 young patients, tracking their brain function, strength, activity levels, and environment t…