HSCT

This phase 3 trial tests whether a lower dose of the chemotherapy drug cyclophosphamide can reduce side effects after a half-matched stem cell transplant for blood cancers. The standard dose often causes complications, so researchers want to see if a lower dose works just as well…

This study tests a drug called gecacitinib in 33 adults who have chronic graft-versus-host disease (cGVHD) after a stem cell transplant and whose condition hasn't improved with steroids. The goal is to find a safe dose and see if it helps control the disease. Participants take th…

This study tests whether the drug gecacitinib, given before, during, and after a stem cell transplant, can help people with myelofibrosis (a type of bone marrow cancer) have better outcomes. About 39 adults aged 18-75 with intermediate- or high-risk myelofibrosis will take part. …

This study tests if luspatercept can help people with blood cancers who have severe anemia after a stem cell transplant. The goal is to see if the drug reduces the need for red blood cell transfusions. About 20 adults aged 18-60 will take part. This is a phase 2 trial, meaning it…

This study tests whether giving focused, high-dose radiation (SBRT) to tumors outside the bone marrow before a donor stem cell transplant can improve outcomes for adults with blood cancers like leukemia or lymphoma. About 20 participants aged 18-60 will receive this combination t…

This phase 2 trial tests whether combining olverembatinib (a targeted pill) with inotuzumab ozogamicin (an antibody-drug conjugate) can clear remaining leukemia cells in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who still have detectable …

This study tests whether a lower dose of the chemotherapy drug treosulfan, given before a stem cell transplant, can help people with Nijmegen breakage syndrome. The condition causes immune problems and a high risk of cancer. The trial will enroll 24 patients, giving a lower dose …

This phase 2 trial tests a new drug called zuberitamab as a first-line treatment for EBV infection in 20 adults who have had a stem cell transplant. EBV can cause a serious complication after transplant, and current treatments don't work for everyone. Zuberitamab is designed to b…

This phase 2 trial tests a reduced-toxicity chemotherapy regimen (thiotepa, melphalan, fludarabine) before a stem cell transplant in 40 people with blast-phase chronic myeloid leukemia (CML), an advanced and hard-to-treat stage. The goal is to see if this gentler approach can imp…

This study will develop and test a prediction tool (nomogram) to estimate the risk of hepatitis B virus reactivation in patients who have had a past infection and are undergoing a stem cell transplant. Researchers will follow 300 patients for at least 36 months after transplant, …

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…