HSCT

This study tests a milder chemotherapy combination (thiotepa and melphalan) given before a stem cell transplant for people with blast phase chronic myeloid leukemia, an advanced and hard-to-treat form of the disease. The goal is to see if this gentler approach can help patients l…

This study tests a lower dose of the drug treosulfan before a stem cell transplant in 24 people with Nijmegen breakage syndrome, a rare genetic condition that weakens the immune system and raises cancer risk. The goal is to see if this approach can safely fix the immune problem a…

This study tests whether the drug gecacitinib can help people with myelofibrosis (a serious bone marrow disorder) who are getting a stem cell transplant. About 39 adults will receive the drug before, during, and after their transplant. The goal is to see if it reduces serious com…

This study tests a new drug called gecacitinib in 33 adults with chronic graft-versus-host disease (cGVHD) that hasn't improved with steroids. The goal is to find a safe dose and see if it can control the disease. Participants must have had a stem cell transplant and have active …

This study tests if a lower dose of a drug called cyclophosphamide can reduce side effects after a stem cell transplant from a half-matched donor in people with blood cancers. About 180 adults will be randomly assigned to receive either the standard or a reduced dose. The goal is…

This study tests whether giving focused radiation (SBRT) before a stem cell transplant can improve outcomes for adults with blood cancers that have spread outside the bone marrow. About 20 participants aged 18-60 will receive the radiation followed by a donor stem cell transplant…

This study tests whether a combination of two drugs (olverembatinib and inotuzumab ozogamicin) can eliminate leftover leukemia cells in adults with a certain type of acute lymphoblastic leukemia (Ph+ ALL) who still have detectable disease after initial treatment. The goal is to a…

This study tests a new medicine called zuberitamab for people who develop an EBV infection after a stem cell transplant. EBV can cause a serious condition called PTLD, which can be fatal if not treated. The drug targets infected cells to clear the virus and prevent complications.…

This study tests if luspatercept can improve anemia in 20 adults with blood cancers who had a stem cell transplant. The goal is to reduce the need for red blood cell transfusions. Participants must be 18-60 and have low hemoglobin after transplant.

This study will follow 400 people receiving stem cell transplants for blood cancers to better understand why some develop serious heart problems. Researchers will use heart scans, blood tests, and other monitoring to find early warning signs. The goal is to improve follow-up care…

This study follows 100 children who receive a stem cell transplant to see how their thinking skills change over one year. Researchers will test memory, attention, and physical abilities before and after the transplant. They also look at factors like activity levels and environmen…