HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Clinical trials for HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH) explained in plain language.
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CRISPR therapy takes aim at stubborn high cholesterol in first human trial
Disease control Recruiting nowThis early-stage trial tests a new CRISPR-based treatment called CTX310 for people with severe cholesterol and triglyceride problems that don't improve with standard therapies. The treatment uses a tiny fat bubble to deliver gene-editing tools that turn off a gene linked to high …
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: PHASE1 • Sponsor: CRISPR Therapeutics AG • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New drug shows promise for rare high cholesterol condition
Disease control Recruiting nowThis study tests an experimental drug called EDP167 in 20 adults with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing very high cholesterol. The drug aims to lower harmful cholesterol levels. Participants will receive multiple injections of EDP16…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: PHASE2 • Sponsor: Eddingpharm (Zhuhai) Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New hope for rare cholesterol disease: can evinacumab shrink dangerous plaque?
Disease control Recruiting nowThis study follows about 52 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol and early heart disease. Researchers will compare those who get evinacumab (a cholesterol-lowering antibody) added to their usual t…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Sponsor: Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi) • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New study screens newborns for inherited high cholesterol
Knowledge-focused Recruiting nowThis study aims to identify different types of familial hypercholesterolemia (FH) in infants and newborns. Expectant parents with FH will provide a cheek swab for genetic testing, and their babies will have 5 blood samples collected over 2 years. The goal is to improve early dete…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC