HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Clinical trials for HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH) explained in plain language.
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New hope for rare cholesterol disease: drug may shrink artery plaque
Disease control Recruiting nowThis study looks at whether adding the drug evinacumab to standard cholesterol treatment can reduce or slow the buildup of plaque in the arteries of people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. About 52 …
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Sponsor: Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi) • Aim: Disease control
Last updated May 17, 2026 04:16 UTC
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New hope for rare cholesterol disease: experimental drug enters phase 2 trial
Disease control Recruiting nowThis study tests an experimental drug called EDP167 in 20 adults with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing very high cholesterol. The drug aims to lower harmful cholesterol levels. Participants will receive multiple injections and be m…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: PHASE2 • Sponsor: Eddingpharm (Zhuhai) Co., Ltd. • Aim: Disease control
Last updated May 08, 2026 12:02 UTC
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CRISPR injection targets stubborn high cholesterol in first human trial
Disease control Recruiting nowThis early-phase study tests a single-dose CRISPR treatment (CTX310) designed to edit a gene that controls fat levels in the blood. It is for adults aged 18 to 75 with severe high cholesterol or triglycerides that do not improve with standard medications. The main goal is to chec…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: PHASE1 • Sponsor: CRISPR Therapeutics AG • Aim: Disease control
Last updated May 04, 2026 16:19 UTC
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New study screens newborns for inherited high cholesterol
Knowledge-focused Recruiting nowThis study aims to find different types of familial hypercholesterolemia (FH) in newborns. Parents will provide a cheek swab for genetic testing, and babies will have five blood samples collected over two years. The goal is to better understand and diagnose this inherited conditi…
Matched conditions: HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HOFH)
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated May 15, 2026 11:53 UTC