HEALTHY ADULT SUBJECTS

This early-phase trial tested an oral form of edaravone in 74 healthy adult males to see how safe it is and how the body processes it. Participants received single or multiple doses of the drug or a placebo. The study is complete and focused on gathering basic safety and drug-lev…

This study looked at how eating different types of meals affects the way the body absorbs oral edaravone, a medication used for ALS. Sixteen healthy Japanese adults took the drug under five different dietary conditions, including fasting. The goal was to understand how food chang…

This completed Phase 1 study looked at how an oral form of edaravone interacts with three other drugs (rosuvastatin, sildenafil, and furosemide) in healthy adult men. It also compared how Japanese and Caucasian men process edaravone. The goal was to gather safety and drug-level d…

This study looked at how the drug edaravone enters the body when given as a liquid by mouth or through a nasogastric tube (a thin tube that goes through the nose to the stomach). It involved 36 healthy Japanese adults aged 20 to 45. The main goal was to measure drug levels in the…

This study tested whether an oral suspension of edaravone works as well as the intravenous (IV) form in 42 healthy Japanese adults. Participants received a single dose of each version, and researchers measured drug levels in the blood to compare them. The goal was to see if the o…

This study tested whether MCI-186, an experimental drug, changes the heart's electrical activity (QT interval) in 27 healthy adult men. Participants received a low dose, a high dose, and a placebo on separate days. The goal was to see if the drug could cause dangerous heart rhyth…

This study tests whether giving pegilodecakin (a biologic drug) via a prefilled syringe works the same as drawing it from a vial into a standard syringe. Healthy adults receive a single dose by each method, and researchers measure how fast the drug enters the bloodstream and how …

This trial investigates how the drug pegilodecakin is absorbed and cleared from the body when given as a single injection at different doses and in different formulations. It involves 12 healthy adults aged 18 to 55. The goal is to measure key drug levels in the blood to guide fu…

This study tested a new tablet version of the drug edaravone (called TTYP01) in 29 healthy adults. The goal was to see if the tablet works the same as the current injection and oral liquid forms. Participants took each form once, and researchers measured drug levels in the blood …

This study tested how a new medicine called SIM0718 moves through the body in 178 healthy adults in China. Participants received a single injection, and researchers measured drug levels, safety, and immune reactions. The goal was to understand the drug's basic behavior before tes…

This study tested whether giving ADL-018 with an autoinjector works the same as with a syringe. 150 healthy adults received a single dose under the skin. The goal was to compare how the drug enters the bloodstream and check for safety. This is an early-stage study, not meant to t…