HEALTHY ADULT SUBJECTS

This early-phase study tested an oral form of edaravone in 74 healthy adult men to see how safe it is and how the body processes it. Participants took single or multiple doses of the drug or a placebo. The goal was to gather basic safety and drug-level data, not to treat any dise…

This study tested whether giving ADL-018 with an autoinjector works the same as with a syringe. 150 healthy adults received a single dose under the skin. The goal was to compare how the drug enters the bloodstream and check for safety. This is an early-stage study, not meant to t…

This study looked at how the drug edaravone enters the body when given as a liquid by mouth or through a nasogastric tube (a thin tube that goes through the nose to the stomach). It involved 36 healthy Japanese adults aged 20 to 45. The main goal was to measure drug levels in the…

This study tested whether an oral suspension of edaravone is processed by the body the same way as the IV form. Forty-two healthy Japanese adults received a single dose of each version. The goal was to see if the oral form could be a suitable alternative to the injection.

This study looked at how eating different types of meals affects the way the body absorbs oral edaravone, a medication used for ALS. Sixteen healthy Japanese adults took the drug under five different dietary conditions, including fasting. The goal was to understand how food chang…

This study tested a new tablet version of the drug edaravone (called TTYP01) in 29 healthy adults. The goal was to see if the tablet works the same as the current injection and oral liquid forms. Participants took each form once, and researchers measured drug levels in the blood …

This study tested whether MCI-186, an experimental drug, changes the heart's electrical activity (QT interval) in 27 healthy adult men. Participants received a low dose, a high dose, and a placebo on separate days. The goal was to see if the drug could cause dangerous heart rhyth…

This study looked at how an oral form of edaravone interacts with three other drugs (rosuvastatin, sildenafil, furosemide) in healthy adult males. It also compared how the drug works in Japanese and Caucasian men. The goal was to gather safety and drug-level data, not to treat an…

This study tested how a new medicine called SIM0718 moves through the body in 178 healthy adults in China. Participants received a single injection, and researchers measured drug levels, safety, and immune reactions. The goal was to understand the drug's basic behavior before tes…