BEHAVIORAL SYMPTOMS

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests a remote, non-drug program called Regulating Together for children ages 8-17 with tuberous sclerosis complex who have emotional or behavioral issues like tantrums or aggression. About 105 children and their caregivers will participate from home using video calls.…

This study is testing a program that combines therapy (CBT) with a team of caring adults chosen by the teen to help prevent suicide. Researchers want to see if Black teens aged 12-17 who are at risk for suicide find this program acceptable and practical. The study will enroll 15 …

This study aims to learn more about how depression, bipolar disorder, and suicide risk affect people and how treatments work. Researchers will follow 500 adults already receiving care at the NIH, using interviews, questionnaires, and optional tests like blood draws and brain scan…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use brain scans to see if a nerve stimulation treatment changes how the brain controls the bladder. The goal is to understand why some children hav…

This study looks at bacteria found in urine, the genital area, and stool of children with overactive bladder and daytime wetting, and compares them to healthy children. Researchers want to see if these bacterial communities are different and if they change with treatment or age. …

This study explores whether placing community health workers in rural schools can help students with poor attendance by addressing their social and health needs. About 38 students in grades 6-12 and their families will receive support from a health worker, while another group wil…