Type III hypersensitivity disease

MONDO:0007004

Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa.

Also known as: disorder of type III hypersensitivity, type 3 hypersensitivity reaction, type III hypersensitivity, type III hypersensitivity reaction, hypersensitivity reaction type III disease

43 clinical trials for this condition and its sub-types, 3 tagged with Type III hypersensitivity disease itself.

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Where it sits in the disease tree

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↑ Autoimmune disease (4049) ↑ Hypersensitivity reaction disease (1025)

Sub-types of Type III hypersensitivity disease

Serum sickness 3 trials
Arthus reaction 0 trials

Including sub-types (43) Tagged with Type III hypersensitivity disease (3)

Trials to join now! 1 Not yet finished but already full! 1 Completed 1

New drug aims to ease daily misery of rare mast cell disease

Symptom relief Ongoing

This phase 2 study tests whether the experimental drug bezuclastinib can reduce symptoms like itching, flushing, and fatigue in people with nonadvanced systemic mastocytosis, a rare condition where too many mast cells cause chronic discomfort. About 237 adults whose symptoms are …

Phase 2 • Sponsor: Cogent Biosciences, Inc. • Aim: Symptom relief

Last updated Jun 27, 2026 12:37 UTC

Type III hypersensitivity disease

Where it sits in the disease tree

New drug aims to ease daily misery of rare mast cell disease