Substance withdrawal syndrome
MONDO:0005567A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
Also known as: drug withdrawal, drug withdrawal syndrome, substance withdrawal, substance withdrawal disorder, substance withdrawal syndrome, withdrawal syndrome, withdrawal disorder
158 clinical trials for this condition and its sub-types, 30 tagged with Substance withdrawal syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance withdrawal syndrome
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Neonatal abstinence syndrome 18 trials
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Alcohol withdrawal 11 trials · 13 incl. sub-types
1 sub-type
- Alcohol withdrawal delirium 2 trials
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Baclofen withdrawal syndrome 0 trials
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Earpiece could cut morphine use for Opioid-Dependent newborns
Symptom relief OngoingThis study tests whether a gentle nerve-stimulating earpiece can help newborns going through opioid withdrawal. The device is used up to four times a day for 20 days, just before each morphine dose. Researchers want to see if it reduces the number of days babies need morphine and…
Sponsor: Spark Biomedical, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New sublingual film could make opioid withdrawal less miserable
Symptom relief OngoingThis study tests a new sublingual film called BXCL501 (dexmedetomidine) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, muscle pain, and nausea. About 160 adults with opioid use disorder will receive the drug, a placebo, or an existing medication (lofexidine…
Phase 1/2 • Sponsor: New York State Psychiatric Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Could a simple drug ease withdrawal in Opioid-Exposed newborns?
Symptom relief OngoingThis study tests an oral drug called lofexidine in newborns who are going through opioid withdrawal because their mothers used opioids during pregnancy. The drug is added to standard care (which includes non-drug support and morphine when needed). The goal is to see if lofexidine…
Phase 2 • Sponsor: BioCorRx Pharmaceuticals Inc • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC