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Squamous cell carcinoma
MONDO:0005096A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.
Also known as: carcinoma, squamous cell, malignant, epidermoid carcinoma, epidermoid cell cancer, malignant epidermoid cell neoplasm, malignant epidermoid cell tumor, malignant epidermoid cell tumour, malignant squamous cell neoplasm, malignant squamous cell tumor
4409 clinical trials for this condition and its sub-types, 177 tagged with Squamous cell carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Squamous cell carcinoma
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Head and neck squamous cell carcinoma 831 trials · 1,057 incl. sub-types
13 sub-types
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Lip and oral cavity squamous cell carcinoma 21 trials · 159 incl. sub-types Sub-types →
- Laryngeal squamous cell carcinoma 72 trials · 77 incl. sub-types Sub-types →
- Nasal cavity and paranasal sinus squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Nasopharyngeal squamous cell carcinoma 12 trials
- Paranasal sinus squamous cell carcinoma 11 trials Sub-types →
- Nasal cavity squamous cell carcinoma 6 trials
- External ear squamous cell carcinoma 1 trial
- Conjunctival squamous cell carcinoma 0 trials
- Cornea squamous cell carcinoma 0 trials
- Lacrimal gland squamous cell carcinoma 0 trials
- Middle ear squamous cell carcinoma 0 trials
- Primary intraosseous squamous cell carcinoma 0 trials
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Esophageal squamous cell carcinoma 306 trials · 307 incl. sub-types
4 sub-types
- Esophageal adenosquamous carcinoma 3 trials
- Undifferentiated carcinoma of esophagus 1 trial
- Esophageal basaloid carcinoma 0 trials
- Esophagus verrucous carcinoma 0 trials
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Skin squamous cell carcinoma 151 trials · 158 incl. sub-types
9 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Anal margin squamous cell carcinoma 4 trials
- Acantholytic squamous cell skin carcinoma 1 trial
- Clear cell squamous cell skin carcinoma 1 trial
- Sarcomatoid squamous cell skin carcinoma 1 trial
- Plantar verrucous skin carcinoma 0 trials
- Pseudovascular skin squamous cell carcinoma 0 trials
- Skin adenosquamous carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
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Squamous cell lung carcinoma 66 trials · 146 incl. sub-types
2 sub-types
- Non-small cell squamous lung carcinoma 84 trials · 89 incl. sub-types Sub-types →
- Lung occult squamous cell carcinoma 0 trials
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Human papillomavirus-related squamous cell carcinoma 115 trials · 116 incl. sub-types
1 sub-type
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Colorectal squamous cell carcinoma 1 trial · 54 incl. sub-types
3 sub-types
- Squamous cell carcinoma of rectum 8 trials · 53 incl. sub-types Sub-types →
- Colorectal adenosquamous carcinoma 0 trials Sub-types →
- Squamous cell carcinoma of colon 0 trials Sub-types →
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Adenosquamous carcinoma 8 trials · 45 incl. sub-types
15 sub-types
- Cervical adenosquamous carcinoma 16 trials Sub-types →
- Pancreatic adenosquamous carcinoma 13 trials
- Adenosquamous lung carcinoma 5 trials
- Esophageal adenosquamous carcinoma 3 trials
- Endometrial adenosquamous carcinoma 2 trials
- Bartholin gland adenosquamous carcinoma 0 trials
- Adenosquamous breast carcinoma 0 trials
- Adenosquamous prostate carcinoma 0 trials
- Colorectal adenosquamous carcinoma 0 trials Sub-types →
- Gallbladder adenosquamous carcinoma 0 trials
- Gastric adenosquamous carcinoma 0 trials
- Liver adenosquamous carcinoma 0 trials Sub-types →
- Salivary gland adenosquamous carcinoma 0 trials
- Skin adenosquamous carcinoma 0 trials
- Thymic adenosquamous carcinoma 0 trials
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Cervical squamous cell carcinoma 36 trials · 40 incl. sub-types
7 sub-types
- Cervical adenosquamous carcinoma 16 trials Sub-types →
- Cervical basaloid carcinoma 0 trials
- Cervical keratinizing squamous cell carcinoma 0 trials
- Cervical lymphoepithelioma-like carcinoma 0 trials
- Cervical non-keratinizing squamous cell carcinoma 0 trials
- Cervical verrucous carcinoma 0 trials
- Microinvasive cervical squamous cell carcinoma 0 trials
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Metastatic squamous cell carcinoma 39 trials
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Squamous cell carcinoma of penis 21 trials · 29 incl. sub-types
5 sub-types
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Vulvar squamous cell carcinoma 22 trials
6 sub-types
- Bartholin gland squamous cell carcinoma 0 trials Sub-types →
- Vulva verrucous carcinoma 0 trials
- Vulvar basaloid squamous cell carcinoma 0 trials
- Vulvar keratinizing squamous cell carcinoma 0 trials
- Vulvar keratoacanthoma-like carcinoma 0 trials
- Vulvar non-keratinizing squamous cell carcinoma 0 trials
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Squamous cell carcinoma of pancreas 3 trials · 13 incl. sub-types
1 sub-type
- Pancreatic adenosquamous carcinoma 13 trials
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Bone squamous cell carcinoma 0 trials · 11 incl. sub-types
1 sub-type
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Squamous carcinoma in situ 5 trials · 10 incl. sub-types
3 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Penis carcinoma in situ 1 trial
- Trachea carcinoma in situ 0 trials
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Vaginal squamous cell carcinoma 8 trials
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Bladder squamous cell carcinoma 5 trials
2 sub-types
- Bladder urachal squamous cell carcinoma 0 trials
- Bladder verrucous carcinoma 0 trials
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Basaloid squamous cell carcinoma 2 trials · 5 incl. sub-types
7 sub-types
- Anus basaloid carcinoma 3 trials
- Basaloid carcinoma of the penis 0 trials
- Cervical basaloid carcinoma 0 trials
- Esophageal basaloid carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
- Thymic basaloid carcinoma 0 trials
- Vulvar basaloid squamous cell carcinoma 0 trials
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Gastric squamous cell carcinoma 4 trials
1 sub-type
- Gastric adenosquamous carcinoma 0 trials
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Papillary squamous carcinoma 1 trial · 4 incl. sub-types
2 sub-types
- Verrucous carcinoma 0 trials · 3 incl. sub-types Sub-types →
- Papillary carcinoma of the penis 0 trials Sub-types →
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Ovarian squamous cell carcinoma 2 trials
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Urethra squamous cell carcinoma 2 trials
1 sub-type
- Urethral verrucous carcinoma 0 trials
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Endometrial squamous cell carcinoma 0 trials · 2 incl. sub-types
1 sub-type
- Endometrial adenosquamous carcinoma 2 trials
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Scrotum squamous cell carcinoma 1 trial
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1 sub-type
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Ureter squamous cell carcinoma 1 trial
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Keratinizing squamous cell carcinoma 0 trials · 1 incl. sub-types
8 sub-types
- Acantholytic squamous cell skin carcinoma 1 trial
- Clear cell squamous cell skin carcinoma 1 trial
- Sarcomatoid squamous cell skin carcinoma 1 trial
- Cervical keratinizing squamous cell carcinoma 0 trials
- Large cell keratinizing variant squamous cell breast carcinoma 0 trials
- Pseudovascular skin squamous cell carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
- Vulvar keratinizing squamous cell carcinoma 0 trials
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Gallbladder squamous cell carcinoma 0 trials
1 sub-type
- Gallbladder adenosquamous carcinoma 0 trials
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Prostate squamous cell carcinoma 0 trials
1 sub-type
- Adenosquamous prostate carcinoma 0 trials
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Renal pelvis squamous cell carcinoma 0 trials
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Sarcomatoid squamous cell carcinoma 0 trials
2 sub-types
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Squamous cell breast carcinoma 0 trials
4 sub-types
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2 sub-types
- Liver adenosquamous carcinoma 0 trials Sub-types →
- Squamous cell bile duct carcinoma 0 trials Sub-types →
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Thymus squamous cell carcinoma 0 trials
2 sub-types
- Thymic adenosquamous carcinoma 0 trials
- Thymic basaloid carcinoma 0 trials
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Trachea squamous cell carcinoma 0 trials
1 sub-type
- Trachea carcinoma in situ 0 trials
Most studied deeper sub-types
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Personalized mRNA cancer vaccine trial halted midway
Disease control Stopped earlyThis study tested a personalized mRNA vaccine (mRNA-4157) combined with the immunotherapy drug pembrolizumab for people with advanced but removable skin cancer (cutaneous squamous cell carcinoma). The goal was to see if the combination could prevent the cancer from coming back be…
Phase 2/3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Immunotherapy combo tested for tough head and neck cancers
Disease control Stopped earlyThis early-phase trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemoradiation is safe for people with stage IV head and neck cancer. Only 3 patients were enrolled before the study was stopped. The main goal was to find the highest safe do…
Phase 1 • Sponsor: Royal Marsden NHS Foundation Trust • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New cancer drug OC-001 tested in advanced tumors – trial ends early
Disease control Stopped earlyThis early-phase trial tested an experimental drug called OC-001, given alone or with the immunotherapy avelumab, in 73 people with various advanced or metastatic cancers (like lung, breast, and bladder cancer). The main goals were to check safety and how the drug moves through t…
Phase 1/2 • Sponsor: Ocellaris Pharma, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Peptide vaccine shows promise in head and neck cancer trial
Disease control Stopped earlyThis study tested a peptide-based immunotherapy in 17 people with head and neck cancer who were scheduled for surgery. The goal was to see if the vaccine could boost the immune system's attack on cancer cells and to check for side effects. The trial was stopped early, but the res…
Phase 2 • Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Radioactive seeds zapped tumors from the inside — but trial stopped early
Disease control Stopped earlyThis early study tested a device that places radioactive seeds directly into skin, mouth, or soft tissue tumors. The seeds release alpha radiation to kill cancer cells from within. Only 2 people took part before the trial was stopped, so we don't have enough information to know i…
Sponsor: Alpha Tau Medical LTD. • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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AI mole checker tested at home – but trial stops early
Diagnosis Stopped earlyThis study tested whether a device called the Sklip System, which uses artificial intelligence, could help people at home decide if a mole might be skin cancer. Only one person took part before the study was stopped early. The goal was to see if the AI could match or beat standar…
Sponsor: OHSU Knight Cancer Institute • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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Lung cancer biomarker study halted after enrolling only 22 patients
Knowledge-focused Stopped earlyThis study aimed to find genetic changes in lung tissue and blood that could predict how squamous cell lung cancer progresses. Researchers planned to collect samples from 200 patients undergoing lung procedures, but the study was stopped early with only 22 participants. No treatm…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC