Squamous carcinoma in situ

MONDO:0004693

A malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues.

Also known as: carcinoma, squamous cell, in situ, malignant, epidermoid carcinoma in situ, epidermoid cell carcinoma in situ, grade 3 SIN, grade 3 squamous intraepithelial neoplasia, grade III SIN, grade III squamous intraepithelial neoplasia, intraepithelial squamous cell carcinoma

2756 clinical trials for this condition and its sub-types, 5 tagged with Squamous carcinoma in situ itself.

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Where it sits in the disease tree

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Part of

↑ Squamous cell carcinoma (1766) ↑ In situ carcinoma (318)

Sub-types of Squamous carcinoma in situ

Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types
1 sub-type
- Bowen disease of the skin 2 trials
Penis carcinoma in situ 1 trial
Trachea carcinoma in situ 0 trials

Including sub-types (2756) Tagged with Squamous carcinoma in situ (5)

Trials to join now! 2 Not yet recruiting 2 Completed 1

DNA vaccine shows promise against anal precancer in HIV patients

Disease control Completed

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

Phase 2 • Sponsor: AIDS Malignancy Consortium • Aim: Disease control

Last updated Jul 10, 2026 00:00 UTC

Squamous carcinoma in situ

Where it sits in the disease tree

DNA vaccine shows promise against anal precancer in HIV patients