Spinocerebellar ataxia type 28

MONDO:0012450

Spinocerebellar ataxia type 28 (SCA28) is a very rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I). It is characterized by juvenile onset, slowly progressive cerebellar ataxia due to Purkinje cell degeneration.

Also known as: SCA28, spinocerebellar ataxia type 28, spinocerebellar ataxia 28

32 clinical trials for this condition and its sub-types, 0 tagged with Spinocerebellar ataxia type 28 itself.

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Where it sits in the disease tree

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↑ Mitochondrial oxidative phosphorylation disorder (58) ↑ Autosomal dominant cerebellar ataxia type I (16)

Including sub-types (32) Tagged with Spinocerebellar ataxia type 28 (0)

Trials to join now! 18 Not yet recruiting 3 Not yet finished but already full! 6 Completed 4 Terminated 1

New drug aims to tame hard-to-control seizures in rare mitochondrial disorders

Disease control Stopped early

This study tested a drug called vatiquinone in 68 people with mitochondrial disease and epilepsy that doesn't respond to standard treatments. Participants were randomly assigned to receive either vatiquinone or a placebo for 24 weeks to see if the drug could reduce the number of …

Phase 2/3 • Sponsor: PTC Therapeutics • Aim: Disease control

Last updated Jun 27, 2026 12:03 UTC

Spinocerebellar ataxia type 28

Where it sits in the disease tree

New drug aims to tame hard-to-control seizures in rare mitochondrial disorders