Schistosomiasis
MONDO:0015254An infectious disease caused by parasitic trematodes of the genus Schistosoma that colonize human blood vessels and release eggs that can cause granulomatous reactions leading to acute (swimmer's itch or acute schistosomiasis syndrome) or chronic disease. Depending on where the eggs lodge, manifestations of chronic schistosomiasis can include diarrhea, abdominal pain, loss of appetite, anemia (intestines), hepatosplenism, periportal fibrosis with portal hypertension (liver), urogenital inflammation and scarring, hematuria and dysuria (genitourinary system). Other patients may be asymptomatic.
Also known as: Bilharzia, bilharziasis, schistosomiasis, snail fever
18 clinical trials for this condition and its sub-types, 15 tagged with Schistosomiasis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Schistosomiasis
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Urinary schistosomiasis 3 trials
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Cercarial dermatitis 0 trials
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Intestinal schistosomiasis 0 trials
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Neuroschistosomiasis 0 trials
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Could a vaccine finally stop the 'Snail Fever'?
Vaccine CompletedThis study tested a new vaccine called SchistoShield® in 120 healthy adults in Burkina Faso and Madagascar. The goal was to see if it is safe and triggers an immune response against schistosomiasis, a parasitic disease spread by snails. Participants received three doses of the va…
Phase 1 • Sponsor: International Vaccine Institute • Aim: Vaccine
Last updated Jun 27, 2026 12:25 UTC
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New vaccine trial aims to stop parasitic worm infection in its tracks
Vaccine CompletedThis study tested a new vaccine (Sm-TSP-2) to protect against intestinal schistosomiasis, a parasitic worm infection common in parts of Africa. Healthy adults in Uganda received different doses of the vaccine, with or without an immune booster, to check safety and how well it tri…
Phase 1/2 • Sponsor: Baylor College of Medicine • Aim: Vaccine
Last updated Jun 27, 2026 07:56 UTC
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Higher dose of schistosomiasis drug shows promise for toddlers
Disease control CompletedThis study tested two doses (40 vs 80 mg/kg) of praziquantel in 354 children aged 1-4 with schistosomiasis in Uganda. The goal was to find the best dose to cure the infection and improve growth and anemia. Currently, praziquantel is not approved for children under 4, and this tri…
Phase 2 • Sponsor: Rhode Island Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New study puts schistosomiasis tests to the test in Near-Elimination zone
Diagnosis CompletedThis completed study in Pemba, Tanzania, compared several diagnostic tests for Schistosoma haematobium, a parasitic worm that causes a debilitating disease. Researchers tested 801 schoolchildren using methods like urine filtration, AI microscopy, and molecular tests. The goal was…
Sponsor: Stefanie Knopp • Aim: Diagnosis
Last updated Jun 26, 2026 19:19 UTC
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Deworming through doctor visits: a smarter way to fight worms?
Knowledge-focused CompletedThis study tested whether giving deworming drugs during regular healthcare visits works better than the usual special campaigns. Over 1,200 people in Western Kenya took part, including community members, health workers, and officials. Researchers measured how practical, affordabl…
Sponsor: Amref Health Africa • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Can community health volunteers boost schistosomiasis awareness in schools?
Knowledge-focused CompletedThis study surveyed nearly 1,000 students in Pemba, Zanzibar, to see how much they know about schistosomiasis (a parasitic disease) and how they feel about it. Researchers tested a health education program led by community volunteers to see if it improves students' knowledge, att…
Sponsor: Pemba Ministry of Health Zanzibar • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC