Progressive supranuclear palsy

MONDO:0019037

A rare late-onset neurodegenerative disease characterized by supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia.

Also known as: PSP syndrome, Steele-Richardson-Olszewski disease, Steele-Richardson-Olszewski syndrome, progressive supranuclear ophthalmoplegia, familial progressive supranuclear palsy (type), supranuclear palsy, progressive

90 clinical trials for this condition and its sub-types, 74 tagged with Progressive supranuclear palsy itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Syndromic disease (7158) ↑ Inherited neurodegenerative disorder (808) ↑ Movement disorder (805) ↑ Supranuclear oculomotor palsy (78)

Sub-types of Progressive supranuclear palsy

Supranuclear palsy, progressive, 1 5 trials
Atypical progressive supranuclear palsy syndrome 1 trial · 4 incl. sub-types
4 sub-types
Supranuclear palsy, progressive, 2 0 trials
Supranuclear palsy, progressive, 3 0 trials

Including sub-types (90) Tagged with Progressive supranuclear palsy (74)

Trials to join now! 33 Not yet recruiting 7 Not yet finished but already full! 17 Completed 16 Terminated 1

Experimental drug aims to curb disinhibition in dementia patients

Symptom relief Stopped early

This study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated ear…

Phase 2 • Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. • Aim: Symptom relief

Last updated Jun 27, 2026 12:32 UTC

Progressive supranuclear palsy

Where it sits in the disease tree

Experimental drug aims to curb disinhibition in dementia patients