Pigment dispersion syndrome
MONDO:0010896Pigment-dispersion syndrome is an eye disorder that occurs when pigment granules that normally adhere to the back of the iris (the colored part of the eye) flake off into the clear fluid produced by the eye (aqueous humor). These pigment granules may flow towards the drainage canals of the eye, slowly clogging them and raising the pressure within the eye (intraocular pressure or IOP). This rise in eye pressure can cause damage to the optic nerve (the nerve in the back of the eye that carries visual images to the brain). If the optic nerve becomes damaged, pigment-dispersion syndrome becomes pigmentary glaucoma. This happens in about 30% of cases. Pigment-dispersion syndrome commonly presents between the second and fourth decades, which is earlier than other types of glaucoma. While men and women are affected in equal numbers, men develop pigmentary glaucoma up to 3 times more often than women. Myopia (nearsightedness) appears to be an important risk factor in the development of pigment-dispersion syndrome and is present in up to 80% of affected individuals. The condition may be sporadic or follow an autosomal dominant pattern of inheritance with reduced penetrance. At least one gene locus on chromosome 7 has been identified. Pigment-dispersion syndrome can be treated with eye drops or other medications. In some cases, laser surgery may be performed.
Also known as: glaucoma-related pigment dispersion syndrome, pigment dispersion syndrome, GPDS1, glaucoma, pigment-dispersion type, glaucoma-RELATED pigment dispersion syndrome, pigment-dispersion syndrome
12 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
New laser zaps eye pressure in seconds for glaucoma patients
Disease control Recruiting nowThis study tests a new laser treatment called Direct Selective Laser Trabeculoplasty (DSLT) for people with pigmentary glaucoma, a type of glaucoma that can lead to vision loss. The laser is applied directly through the eye's surface in just a few seconds, aiming to lower high ey…
Sponsor: Mann Eye Institute • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
-
New eye implant could rival standard glaucoma surgery
Disease control Recruiting nowThis study tests whether a tiny drainage device called the Preserflo MicroShunt can lower eye pressure as well as the standard trabeculectomy surgery in adults with open-angle glaucoma. One hundred participants will be randomly assigned to receive one of the two procedures and wi…
Phase: NA • Sponsor: Medical University of Bialystok • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
-
Could a mild eye zap help restore sight in glaucoma?
Disease control Recruiting nowThis study tests whether a weak electrical current applied to the eye's surface can improve vision in people with open-angle glaucoma. Fifty adults with worsening vision loss will receive either real or sham stimulation over several sessions. The goal is to see if this safe, non-…
Phase: NA • Sponsor: Okuvision GmbH • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
-
Eye screening study opens doors to future research
Knowledge-focused Recruiting nowThis study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
-
New eye camera could catch blindness before it starts
Knowledge-focused Recruiting nowThis study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
-
Scientists watch and treat eye diseases to unlock their secrets
Knowledge-focused Recruiting nowThis study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
-
AI-Powered summaries aim to make eye care notes clearer for patients
Knowledge-focused Recruiting nowThis study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…
Phase: NA • Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
-
New 4D eye scanner debuts in operating room
Knowledge-focused Recruiting nowThis study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
-
VR headset tracks eyes to unlock new diagnostic insights
Knowledge-focused Recruiting nowThis study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…
Sponsor: machineMD AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
-
New eye camera aims to make pediatric exams easier
Knowledge-focused Recruiting nowThis study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC