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Paroxysmal cold hemoglobinuria

MONDO:0019533

Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.

Also known as: Donath-Landsteiner hemolytic anaemia, Donath-Landsteiner hemolytic anemia, Donath-Landsteiner syndrome, PCH, hemoglobinuria paroxysmal cold

40 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Autoimmune disease (305) Anemia (233) Hematologic disorder (170) Immune system disorder (148) Autoimmune hemolytic anemia (48) Hemolytic anemia (19) Human disease (14) Autoimmune hemolytic anemia, cold type (2) Autoimmune disorder of blood (0)

Trials to join now! 16 Not yet recruiting 6 Not yet finished but already full! 7 Completed 10 Terminated 1

Biopsy tolerance study ends early – what we know

Knowledge-focused Terminated

This study aimed to understand how well patients tolerate biopsies for autoimmune diseases and whether they feel properly informed. It planned to enroll 505 people but was terminated early. The results may help improve patient experience with these common procedures.

Sponsor: University Hospital, Brest • Aim: Knowledge-focused

Last updated Jun 28, 2026 00:00 UTC