Parathyroid gland carcinoma
MONDO:0012004A very rare, slow-growing, clinically serious endocrine tumor that generally develops in mid-adulthood. PRTC presents as a palpable painless mass in the neck and causes severe hypercalcemia and related symptoms, non-specific gastrointestinal manifestations, as well as renal and bone complications related to primary hyperparathyroidism (nephrolithiasis, impaired renal function, osteoporosis, bone pain, and pathologic fractures, etc.). Some PRTCs are however non-functioning tumors.
Also known as: cancer of parathyroid gland, cancer of the parathyroid gland, malignant neoplasm of parathyroid gland, malignant neoplasm of the parathyroid, malignant tumour of parathyroid gland, parathyroid cancer, parathyroid gland cancer, parathyroid gland neoplasm
2747 clinical trials for this condition and its sub-types, 4 tagged with Parathyroid gland carcinoma itself.
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Heat therapy may tame parathyroid Cancer's calcium chaos
Disease control Recruiting nowThis study tests whether radiofrequency ablation (using heat to destroy tumors) can safely lower high calcium levels in 20 adults with recurrent parathyroid cancer who cannot have surgery. Participants will have one to five neck tumors treated. The goal is to control the disease …
Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New hope for rare cancers: immunotherapy drug targets tumors regardless of origin
Disease control Recruiting nowThis study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…
Phase 2 • Sponsor: Instituto do Cancer do Estado de São Paulo • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Scientists dig into old tumor samples to outsmart parathyroid cancer
Knowledge-focused Recruiting nowThis study examines stored tumor tissue and blood samples from 310 people with parathyroid tumors. Researchers aim to find molecular and genetic markers that can better distinguish between benign and cancerous tumors. The goal is to reduce misdiagnosis, unnecessary surgery, and s…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC