Paraplegia-intellectual disability-hyperkeratosis syndrome

A syndrome characterized by intellectual deficit, spasticity in the lower limbs (spastic paraplegia), pes cavus deformity of both feet, an abnormal gait, and palmar and plantar hyperkeratosis. It has been reported in four brothers. The mother of the affected boys had normal intelligence, plantar hyperkeratosis and a strong facial resemblance to her retarded sons. Her three daughters were normal. This syndrome most likely an X-linked recessive condition.

Also known as: Fitzsimmons-McLachlan-Gilbert syndrome, intellectual disability with spastic paraplegia and palmoplantar hyperkeratosis, mental retardation with spastic paraplegia and palmoplantar hyperkeratosis

0 clinical trials for this condition and its sub-types, 0 tagged with Paraplegia-intellectual disability-hyperkeratosis syndrome itself.