Paraplegia
MONDO:0003757Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.
Also known as: severe or complete loss of motor function in the lower extremities and lower portions of the trunk
68 clinical trials for this condition and its sub-types, 47 tagged with Paraplegia itself.
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Sub-types of Paraplegia
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Hereditary spastic paraplegia 27 trials · 33 incl. sub-types
45 sub-types
- Complex hereditary spastic paraplegia 1 trial · 7 incl. sub-types Sub-types →
- Hereditary spastic paraplegia 50 3 trials
- Hereditary spastic paraplegia 3A 2 trials
- Hereditary spastic paraplegia 4 2 trials
- Hereditary spastic paraplegia 5A 2 trials
- Hereditary spastic paraplegia 47 1 trial
- Hereditary spastic paraplegia 51 1 trial
- Hereditary spastic paraplegia 52 1 trial
- Hereditary spastic paraplegia 7 1 trial
- ADAR-related hereditary spastic paraplegia 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- IFIH1-related hereditary spastic paraplegia 0 trials
- RNASEH2B-related hereditary spastic paraplegia 0 trials
- Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome 0 trials
- Hereditary spastic paraplegia 10 0 trials
- Hereditary spastic paraplegia 13 0 trials
- Hereditary spastic paraplegia 14 0 trials
- Hereditary spastic paraplegia 16 0 trials
- Hereditary spastic paraplegia 2 0 trials
- Hereditary spastic paraplegia 30 0 trials Sub-types →
- Hereditary spastic paraplegia 31 0 trials
- Hereditary spastic paraplegia 33 0 trials
- Hereditary spastic paraplegia 35 0 trials
- Hereditary spastic paraplegia 48 0 trials
- Hereditary spastic paraplegia 56 0 trials
- Hereditary spastic paraplegia 6 0 trials
- Hereditary spastic paraplegia 77 0 trials
- Macrocephaly-spastic paraplegia-dysmorphism syndrome 0 trials
- Mast syndrome 0 trials
- Pure hereditary spastic paraplegia 0 trials Sub-types →
- Pure or complex hereditary spastic paraplegia 0 trials
- Spastic paraplegia 72b, autosomal recessive 0 trials
- Spastic paraplegia 79A, autosomal dominant, with ataxia 0 trials
- Spastic paraplegia 80, autosomal dominant 0 trials
- Spastic paraplegia 81, autosomal recessive 0 trials
- Spastic paraplegia 82, autosomal recessive 0 trials
- Spastic paraplegia 83, autosomal recessive 0 trials
- Spastic paraplegia 87, autosomal recessive 0 trials
- Spastic paraplegia 88, autosomal dominant 0 trials
- Spastic paraplegia 89, autosomal recessive 0 trials
- Spastic paraplegia 90A, autosomal dominant 0 trials
- Spastic paraplegia 90B, autosomal recessive 0 trials
- Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia 0 trials
- Spastic paraplegia 92, autosomal recessive 0 trials
- Spastic paraplegia 93, autosomal recessive 0 trials
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Brown-Sequard syndrome 0 trials
Most studied deeper sub-types
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Mind over paralysis: Brain-Spine bridge aims to restore leg movement
Disease control OngoingThis study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …
Sponsor: Ecole Polytechnique Fédérale de Lausanne • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Can a smartwatch and coaching help paraplegics cut heart disease risk?
Disease control OngoingThis pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…
Sponsor: Brunel University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Electric rowing machine study for paralysis pulled before it began
Symptom relief CancelledThis study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…
Sponsor: UGECAM Rhône-Alpes • Aim: Symptom relief
Last updated Jun 26, 2026 19:11 UTC
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Mind over paralysis: can thinking about walking reboot the brain?
Knowledge-focused By invitation onlyThis study tests whether a virtual reality brain-machine interface can help people with spinal cord injury regain function. Participants imagine moving their legs while wearing an EEG cap and VR headset, receiving sensory feedback. The goal is to understand how the brain's commun…
Sponsor: José Gabriel da Silva Figueiredo • Aim: Knowledge-focused
Last updated Jul 31, 2026 00:00 UTC
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New study tracks shoulder health in wheelchair users to prevent future pain
Knowledge-focused OngoingThis study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…
Sponsor: The University of Texas Medical Branch, Galveston • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:53 UTC