Non-acquired combined pituitary hormone deficiency

MONDO:0018762

Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis.

Also known as: congenital combined pituitary hormone deficiency, congenital hypopituitarism

3 clinical trials for this condition and its sub-types, 1 tagged with Non-acquired combined pituitary hormone deficiency itself.

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Where it sits in the disease tree

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↑ Non-acquired pituitary hormone deficiency (85)

Sub-types of Non-acquired combined pituitary hormone deficiency

Pallister-Hall syndrome 0 trials · 2 incl. sub-types
1 sub-type
- Congenital hypothalamic hamartoma syndrome 2 trials
ANE syndrome 0 trials
Deficiency in anterior pituitary function - variable immunodeficiency syndrome 0 trials
Holoprosencephaly 0 trials
17 sub-types
- Alobar holoprosencephaly 0 trials Sub-types →
- Chromosome 1q41-q42 deletion syndrome 0 trials
- Holoprosencephaly 1 0 trials
- Holoprosencephaly 10 0 trials
- Holoprosencephaly 11 0 trials
- Holoprosencephaly 12 with or without pancreatic agenesis 0 trials
- Holoprosencephaly 13, X-linked 0 trials
- Holoprosencephaly 14 0 trials
- Holoprosencephaly 2 0 trials
- Holoprosencephaly 3 0 trials Sub-types →
- Holoprosencephaly 4 0 trials
- Holoprosencephaly 6 0 trials
- Holoprosencephaly 7 0 trials
- Holoprosencephaly 8 0 trials
- Lobar holoprosencephaly 0 trials Sub-types →
- Microform holoprosencephaly 0 trials Sub-types →
- Semilobar holoprosencephaly 0 trials
Non-acquired combined pituitary hormone deficiency with spine abnormalities 0 trials
Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome 0 trials
Short stature-pituitary and cerebellar defects-small sella turcica syndrome 0 trials

Most studied deeper sub-types

Holoprosencephaly 5 (0) Holoprosencephaly 9 (0) Solitary median maxillary central incisor syndrome (0)

Including sub-types (3) Tagged with Non-acquired combined pituitary hormone deficiency (1)

Trials to join now! 1

Hope for hypothalamic obesity: daily shot targets weight and hunger

Disease control Recruiting now

This phase 3 trial tests whether a daily injection of setmelanotide can help people aged 4 and older with hypothalamic obesity lose weight and feel less hungry. Participants will receive either the drug or a placebo for 26 weeks. The study aims to see if the treatment leads to me…

Phase 3 • Sponsor: Rhythm Pharmaceuticals, Inc. • Aim: Disease control

Last updated Jun 27, 2026 09:04 UTC

Non-acquired combined pituitary hormone deficiency

Where it sits in the disease tree

Most studied deeper sub-types

Hope for hypothalamic obesity: daily shot targets weight and hunger