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Neurofibroma
MONDO:0016755An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
Also known as: neurofibroma, neurofibroma (WHO grade I), neurofibroma, benign, NFIB
1516 clinical trials for this condition and its sub-types, 17 tagged with Neurofibroma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Neurofibroma
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Neurofibrosarcoma 33 trials
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Plexiform neurofibroma 29 trials
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Atypical neurofibroma 4 trials
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Pacinian tumor 0 trials
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Cellular neurofibroma 0 trials
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Epithelioid neurofibroma 0 trials
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Mediastinum neurofibroma 0 trials
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Neurofibroma of gallbladder 0 trials
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Neurofibroma of spinal cord 0 trials
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Neurofibroma of the esophagus 0 trials
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Neurofibroma of the heart 0 trials
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New gel could shrink neurofibroma tumors without surgery
Disease control CompletedThis phase 2 trial tested a gel called NFX-179 on skin tumors in 199 adults with neurofibromatosis type 1. Participants applied the gel daily for 26 weeks. The study measured safety and whether tumors shrank in size or height. Results suggest the gel may help reduce tumor volume,…
Phase 2 • Sponsor: NFlection Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New Gadolinium-Free MRI dye shows promise for brain scans
Diagnosis CompletedThis study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…
Phase 2 • Sponsor: Reveal Pharmaceuticals Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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Scientists track skin tumors in NF1 to uncover clues for future therapies
Knowledge-focused CompletedThis study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Gene hunt aims to unlock NF1's mysteries
Knowledge-focused CompletedThis study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC