Nephrogenic diabetes insipidus

MONDO:0016383

Nephrogenic diabetes insipidus (NDI) is characterized by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatremic dehydration after birth that may cause neurological sequelae. Polyuria may exceed 10 liters in children.

Also known as: ADH resistant diabetes insipidus, diabetes insipidus nephrogenic, diabetes insipidus nephrogenic X-linked, diabetes insipidus nephrogenic type 1

35 clinical trials for this condition and its sub-types, 1 tagged with Nephrogenic diabetes insipidus itself.

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Where it sits in the disease tree

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Part of

↑ Impaired renal function disease (129) ↑ Inherited renal tubular disease (40) ↑ Diabetes insipidus (38)

Sub-types of Nephrogenic diabetes insipidus

Diabetes insipidus, nephrogenic, X-linked 1 trial
Diabetes insipidus, nephrogenic, autosomal 0 trials

Including sub-types (35) Tagged with Nephrogenic diabetes insipidus (1)

Completed 1

New drug PB shows promise for slowing excessive urination in kidney patients

Symptom relief Completed

This study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…

Phase 2 • Sponsor: Mayo Clinic • Aim: Symptom relief

Last updated Jun 27, 2026 09:00 UTC

Nephrogenic diabetes insipidus

Where it sits in the disease tree

New drug PB shows promise for slowing excessive urination in kidney patients