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Multicentric reticulohistiocytosis

MONDO:0015347

Multicentric reticulohistiocytosis (MRH) is a rare non-Langerhans cell histiocytosis characterized by the association of specific nodular skin lesions and destructive arthritis.

Also known as: giant cell histiocytomatosis, lipoid dermatoarthritis, multicentric reticulohistiocytosis

7 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Immune system disorder (148) Lymphatic system disorder (29) Syndromic disease (25) Histiocytosis (16) Human disease (14) Lymphoid system disorder (1) Non-Langerhans cell histiocytosis (1) Disease by body system or component (0)

Trials to join now! 2 Not yet finished but already full! 4 Completed 1

New drug targets tough childhood cancers with genetic flaws

Disease control Completed

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 27, 2026 12:23 UTC