Malignant peripheral nerve sheath tumor
MONDO:0017827Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma occurring in a wide range of anatomical sites.
Also known as: neurofibrosarcoma, MPNST, Malig. periph. nerve sheath tum., malignant neoplasm of peripheral nerve sheath, malignant neurilemmoma, malignant neurilemoma, malignant neurofibroma, malignant peripheral nerve sheath neoplasm
2944 clinical trials for this condition and its sub-types, 36 tagged with Malignant peripheral nerve sheath tumor itself.
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Sub-types of Malignant peripheral nerve sheath tumor
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Childhood malignant schwannoma 1 trial
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Malignant triton tumor 1 trial
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Adult malignant schwannoma 0 trials
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Can a Two-Drug combo stop a rare, aggressive nerve tumor?
Disease control Not yet recruitingThis phase 2 trial is testing whether the combination of avutometinib and defactinib can stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery. The study enrolls people over 12 years old with relapsed, refractory, met…
Phase 2 • Sponsor: Girish Dhall, MD • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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New imaging agent aims to light up hidden tumors
Diagnosis Not yet recruitingThis early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …
Phase 1 • Sponsor: Robert Flavell, MD, PhD • Aim: Diagnosis
Last updated Jun 27, 2026 14:02 UTC