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Malignant histiocytosis

MONDO:0004612

Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of macrophages and dendritic cells.

Also known as: Stewart's granuloma, histiocytic medullary reticulosis, malignant histiocytic disease, malignant midline reticulosis, malignant reticulosis, disorders, malignant histiocytic, histiocytic disorder, malignant, malignant histiocytic disorders

10 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Immune system disorder (148) Lymphatic system disorder (29) Histiocytosis (16) Human disease (14) Lymphoid system disorder (1) Disease by body system or component (0)

Trials to join now! 5 Not yet finished but already full! 4 Completed 1

New drug targets tough childhood cancers with genetic flaws

Disease control Completed

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 27, 2026 12:23 UTC