Macroglossia

MONDO:0015496

The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)

Also known as: enlarged tongue, giant tongue

2 clinical trials for this condition and its sub-types, 1 tagged with Macroglossia itself.

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Where it sits in the disease tree

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Part of

↑ Developmental defect during embryogenesis (1057) ↑ Disorder of facial skeleton (132)

Sub-types of Macroglossia

Congenital macroglossia 0 trials

Including sub-types (2) Tagged with Macroglossia (1)

Completed 1

Experimental antibody shows promise for rare amyloid disease

Disease control Completed

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers a…

Phase 2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control

Last updated Jun 26, 2026 15:04 UTC

Macroglossia

Where it sits in the disease tree

Experimental antibody shows promise for rare amyloid disease