Leukoplakia
MONDO:0043243A white patch or plaque on a mucous membrane that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc., must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition.
Also known as: keratotic plaque, leukoplakia, lesion, leukoplakic, lesions, leukoplakic, leukokeratoses, leukokeratosis, leukoplakias, leukoplakic lesion
39 clinical trials for this condition and its sub-types, 7 tagged with Leukoplakia itself.
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Sub-types of Leukoplakia
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Oral mucosa leukoplakia 23 trials
1 sub-type
- Leukoplakia of gingiva 0 trials
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Esophageal leukoplakia 1 trial
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Leukoplakia of penis 0 trials
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Leukoplakia of vagina 0 trials
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Uterine cervix leukoplakia 0 trials
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Immunotherapy tackles precancerous mouth spots
Disease control Recruiting nowThis trial tests whether pembrolizumab (Keytruda), an immunotherapy drug that helps the immune system attack abnormal cells, can shrink or control leukoplakia—a precancerous condition of the mouth. The study includes people with leukoplakia or related lesions that cannot be remov…
Phase 2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Could a skin cream treat Pre-Cancerous mouth spots?
Disease control Recruiting nowThis study tests if a cream called imiquimod can treat pre-cancerous spots in the mouth. Twenty adults with these spots will apply the cream and get two follow-up biopsies. The goal is to see if the spots shrink and if the abnormal cells become less severe.
Phase 1/2 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC