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Leiomyosarcoma
MONDO:0005058An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.
Also known as: Leiomyosarcomas, leiomyosarcoma, leiomyosarcoma (excluding uterine leiomyosarcoma), leiomyosarcoma - not uterine, leiomyosarcoma, malignant
2874 clinical trials for this condition and its sub-types, 62 tagged with Leiomyosarcoma itself.
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Sub-types of Leiomyosarcoma
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Leiomyosarcoma of the corpus uteri 9 trials
2 sub-types
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Ovary leiomyosarcoma 2 trials
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Retroperitoneal leiomyosarcoma 2 trials
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Inflammatory leiomyosarcoma 1 trial
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Small intestine leiomyosarcoma 1 trial
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Bone leiomyosarcoma 0 trials
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Breast leiomyosarcoma 0 trials
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1 sub-type
- Granular cell leiomyosarcoma 0 trials
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Colon leiomyosarcoma 0 trials
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Conventional leiomyosarcoma 0 trials
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Cutaneous leiomyosarcoma 0 trials
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Epithelioid leiomyosarcoma 0 trials
1 sub-type
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Esophagus leiomyosarcoma 0 trials
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Fallopian tube leiomyosarcoma 0 trials
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Gallbladder leiomyosarcoma 0 trials
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Gastric leiomyosarcoma 0 trials
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Heart leiomyosarcoma 0 trials
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Kidney leiomyosarcoma 0 trials
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Laryngeal leiomyosarcoma 0 trials
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Leiomyosarcoma of the cervix uteri 0 trials
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Liver leiomyosarcoma 0 trials
1 sub-type
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Lung leiomyosarcoma 0 trials
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Mediastinum leiomyosarcoma 0 trials
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Myxoid leiomyosarcoma 0 trials
1 sub-type
- Uterine corpus myxoid leiomyosarcoma 0 trials
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Prostate leiomyosarcoma 0 trials
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Pulmonary artery leiomyosarcoma 0 trials
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Pulmonary vein leiomyosarcoma 0 trials
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Rectum leiomyosarcoma 0 trials
1 sub-type
- Anus leiomyosarcoma 0 trials
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Superior vena cava leiomyosarcoma 0 trials
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Vagina leiomyosarcoma 0 trials
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Vulvar leiomyosarcoma 0 trials
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New cancer drug BBI-355 trial halted early – what we know
Disease control Stopped earlyThis early-phase trial tested a new oral drug called BBI-355, alone or with other targeted therapies, in people with advanced solid tumors that had extra DNA (oncogene amplifications). The study aimed to find the safest dose and check for side effects. It was terminated early, so…
Phase 1 • Sponsor: Boundless Bio, Inc. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Experimental drug combo for rare sarcoma shows promise, but trial halted early
Disease control Stopped earlyThis phase 3 trial tested whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) could help people with advanced leiomyosarcoma, a rare soft tissue cancer. The study planned to enroll 218 participants whose cancer had progressed after prior treatment. Unfo…
Phase 3 • Sponsor: Polaris Group • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental drug tested for rare cancer, trial stopped early
Disease control Stopped earlyThis study tested a drug called XmAb23104 in people with advanced sarcoma, a rare cancer. The goal was to see if the drug could shrink tumors and if it was safe. Only 6 people took part before the study was ended early.
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC