Large cell neuroendocrine carcinoma

MONDO:0005057

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.

Also known as: LCNEC, large cell NEC, large cell neuroendocrine carcinoma, large-cell neuroendocrine carcinoma

2792 clinical trials for this condition and its sub-types, 12 tagged with Large cell neuroendocrine carcinoma itself.

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↑ Neuroendocrine carcinoma (744) ↑ Large cell carcinoma (87)

Sub-types of Large cell neuroendocrine carcinoma

Pulmonary large cell neuroendocrine carcinoma 20 trials
1 sub-type
- Lung combined large cell neuroendocrine carcinoma 0 trials
Cervical large cell neuroendocrine carcinoma 4 trials
Breast large cell neuroendocrine carcinoma 0 trials
Ovarian large-cell neuroendocrine carcinoma 0 trials
Pancreatic large cell neuroendocrine carcinoma 0 trials
Thymic large cell neuroendocrine carcinoma 0 trials

Including sub-types (2792) Tagged with Large cell neuroendocrine carcinoma (12)

Trials to join now! 7 Not yet recruiting 1 Not yet finished but already full! 3 Completed 1

New combo attack on stubborn cancers shows promise in early trial

Disease control Completed

This phase II trial tests whether combining the immunotherapy drug nivolumab with the chemotherapy drug temozolomide can shrink tumors in people with small-cell lung cancer that has returned or not responded to treatment, or advanced neuroendocrine tumors. About 55 participants w…

Phase 2 • Sponsor: Dwight Owen • Aim: Disease control

Last updated Aug 20, 2026 00:00 UTC

Large cell neuroendocrine carcinoma

Where it sits in the disease tree

New combo attack on stubborn cancers shows promise in early trial