Landau-Kleffner syndrome
MONDO:0009509A rare form of epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) characterized by various combinations of acquired cognitive, language, behavioral, and motor deficits associated with marked spike- and- wave activation in sleep. In Landau-Kleffner syndrome, receptive language is mainly affected, with an acquired auditory verbal agnosia.
Also known as: LKS, Landau-Kleffner syndrome, acquired epileptic aphasia, FESD, Rolandic epilepsy, intellectual disability, and speech dyspraxia, autosomal dominant, Rolandic epilepsy, mental retardation, and speech dyspraxia, autosomal dominant, acquired aphasia with convulsive disorder, acquired epileptiform aphasia
31 clinical trials for this condition and its sub-types.
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Saliva test may unlock genetic secrets missed by blood tests
Diagnosis Not yet recruitingThis study tests whether a simple saliva swab can find genetic causes of neurodevelopmental or intellectual disorders when standard blood tests have not. Researchers will use advanced DNA sequencing on cheek cells from 50 participants. The goal is to improve diagnosis and help gu…
Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Diagnosis
Last updated Jun 27, 2026 12:07 UTC
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French SOSI-M test under study for kids with developmental disorders
Diagnosis Not yet recruitingThis study aims to validate a French translation of the SOSI-M test, which measures sensory integration in children. Researchers will film 60 children (30 healthy, 30 with mild to moderate neurodevelopmental disorders) taking the test and compare scores. The goal is to see if the…
Phase: NA • Sponsor: Haute Ecole Ilya Prigogine • Aim: Diagnosis
Last updated Jun 27, 2026 08:12 UTC
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Can sensory tests improve counseling for kids with developmental disorders?
Knowledge-focused Not yet recruitingThis study will test whether using results from a sensory integration assessment can improve counseling for children aged 3-12 with neurodevelopmental problems like sensory sensitivity or coordination difficulties. Researchers will measure changes in sensory processing and daily …
Sponsor: Yeditepe University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study explores low-tech aids to help non-verbal kids with autism communicate
Knowledge-focused Not yet recruitingThis study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…
Phase: NA • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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New digital Game-Like tests aim to spot learning disorders earlier in kids
Knowledge-focused Not yet recruitingThis study will use a digital platform with game-like tasks to measure thinking and reading skills in 300 children aged 3-11 who are suspected of having a neurodevelopmental disorder. The goal is to create detailed cognitive profiles before a formal diagnosis, helping to identify…
Sponsor: IRCCS Eugenio Medea • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC