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Juvenile primary lateral sclerosis

MONDO:0011663

Juvenile primary lateral sclerosis (JPLS) is a very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production.

Also known as: JPLS, juvenile PLS, PLS juvenile, PLSJ, Pls, juvenile, primary lateral sclerosis, juvenile

9 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Nervous system disorder (231) Hereditary disease (176) Neurodegenerative disease (171) Central nervous system disorder (107) Neuromuscular disease (106) Motor neuron disorder (62) Lateral sclerosis (21) Human disease (14) Inherited neurodegenerative disorder (10)
Trials to join now! 8 Not yet finished but already full! 1
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  • Smart sleeve study aims to improve movement for nerve disease patients

    Knowledge-focused ENROLLING_BY_INVITATION

    This study follows 1000 people with upper motor neuron disease who are about to receive the Cionic Neural Sleeve. The sleeve uses electrical stimulation to help muscles contract at the right time during movement. Researchers will track changes in health-related quality of life us…

    Phase: NA • Sponsor: Cionic, Inc. • Aim: Knowledge-focused

    Last updated Jun 27, 2026 08:04 UTC

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