Isolated congenital megalocornea
MONDO:0010649Isolated congenital megalocornea is a genetic, non-syndromic developmental defect of the anterior eye segment characterized by bilateral enlargement of the corneal diameter (>12.5 mm) and a deep anterior eye chamber, without an elevation in intraocular pressure. It can manifest with mild to moderate myopia as well as photophobia and iridodonesis (due to iris hypoplasia). Associated complications include lens dislocation, retinal detachment, presenile cataract development, and secondary glaucoma.
Also known as: congenital anterior megalophthalmia, isolated congenital megalocornea, megalocornea 1, X-linked, X-linked recessive, MGC1, Mgcn, megalocornea
7 clinical trials for this condition and its sub-types, 0 tagged with Isolated congenital megalocornea itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
-
New eye scanner could sharpen diagnosis of glaucoma and retina diseases
Diagnosis CompletedThis study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…
Sponsor: Intalight, Inc • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
-
New registry aims to improve corneal transplants with AI
Knowledge-focused CompletedThis study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…
Sponsor: Nitin Vaswani • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
-
AI eye chatbot matches doctors in taking patient history
Knowledge-focused CompletedThis study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC