Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression

MONDO:0018314

A rare monogenic disease with infantile-onset pharmacoresistant focal seizures of mesial temporal lobe onset manifesting with unresponsiveness, hypertonia and automatisms and cognitive regression soon after seizure onset leading to severe intellectual disability with behavioral abnormalities.

7 clinical trials for this condition and its sub-types, 0 tagged with Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression itself.

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↑ Monogenic epilepsy (12) ↑ Infantile epilepsy syndrome (10)

Including sub-types (7) Tagged with Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression (0)

Trials to join now! 4 Not yet finished but already full! 2 Completed 1

Routine EEGs may hold hidden clues to childhood epilepsy — a new analysis method is put to the test

Diagnosis Completed

This study is testing whether a computer tool called BioEP can detect signs of seizure susceptibility in standard EEG recordings from children with epilepsy. Researchers will analyze past EEGs from 530 children aged 2 to 18 who already have an epilepsy diagnosis. The goal is to s…

Sponsor: Neuronostics Ltd • Aim: Diagnosis

Last updated Aug 01, 2026 00:00 UTC

Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression

Where it sits in the disease tree

Routine EEGs may hold hidden clues to childhood epilepsy — a new analysis method is put to the test