Incontinentia pigmenti
MONDO:0010631Incontinentia pigmenti (IP) is a rare X-linked dominant multi-systemic ectodermal dysplasia usually lethal in males and presenting neonatally in females with a bullous rash along Blashko's lines (BL) followed by verrucous plaques evolving over time to hyperpigmented swirling patterns. It is further characterized by teeth abnormalities, alopecia, nail dystrophy and affects occasionally the retina and the central nervous system (CNS).
Also known as: Bloch-Siemens syndrome, Bloch-Sulzberger syndrome, Incontinentia pigmenti syndrome, incontinentia pigmenti, incontinentia pigmenti, X-linked dominant, IP, IP2 (formerly), Incontinentia pigmenti type 2 (formerly)
16 clinical trials for this condition and its sub-types.
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Could stem cells restore sight in damaged eyes?
Disease control Recruiting nowThis study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…
Phase: NA • Sponsor: MD Stem Cells • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New eye scanner tested against gold standard for retina diagnosis
Diagnosis Recruiting nowThis study tests a new eye imaging device (VG200D OCT) that takes detailed pictures of the retina. It compares these images to standard dye-based images (FA/ICGA) to see if the new device works just as well. About 30 adults with retina problems will take part. The goal is to see …
Sponsor: Intalight, Inc • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Super camera could catch eye diseases before they steal your sight
Diagnosis Recruiting nowThis study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…
Phase: NA • Sponsor: Center for Eye Research Australia • Aim: Diagnosis
Last updated Jun 27, 2026 12:24 UTC
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Scientists launch eye tissue bank to unlock secrets of retinal disease
Knowledge-focused Recruiting nowThis study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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New eye camera sees cells that may unlock secrets of blindness
Knowledge-focused Recruiting nowThis study uses a special camera (adaptive optics) to take detailed pictures of the back of the eye in people with inherited retinal diseases. Researchers want to see how individual cells change over time and after treatments. About 200 participants aged 5 to 70 will be observed,…
Sponsor: The Hospital for Sick Children • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Can a smartphone dashboard boost mental health care in rwanda?
Knowledge-focused Recruiting nowThis study tests a digital dashboard tool to help community workers deliver a family-based mental health program called Sugira Muryango in Rwanda. The goal is to see if the technology improves how well the program is delivered, including fidelity and worker confidence. Over 1,800…
Phase: NA • Sponsor: Boston College • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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New study to measure hidden toll of rare skin diseases on patients and families
Knowledge-focused Recruiting nowThis study aims to understand the full burden of 9 rare skin diseases—including physical, emotional, social, and financial challenges—on patients and their families. Researchers will use special questionnaires to track how these conditions affect daily life and care needs. About …
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New eye scanner tested on 180 volunteers – no treatment involved
Knowledge-focused Recruiting nowThis study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …
Sponsor: Optos, PLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC