In situ carcinoma
MONDO:0004647A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion.
Also known as: CIS, carcinoma in situ, carcinoma, in situ, malignant, epithelial tumor, in situ, malignant, intraepithelial carcinoma, non-invasive carcinoma, stage 0 disease
3066 clinical trials for this condition and its sub-types, 25 tagged with In situ carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of In situ carcinoma
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Breast carcinoma in situ 76 trials · 204 incl. sub-types
4 sub-types
- Ductal breast carcinoma in situ 152 trials Sub-types →
- Lobular neoplasia 4 trials · 30 incl. sub-types Sub-types →
- Ductal breast carcinoma in situ and lobular carcinoma in situ 1 trial
- Breast apocrine carcinoma in situ 0 trials
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Adenocarcinoma in situ 10 trials · 170 incl. sub-types
3 sub-types
- Ductal breast carcinoma in situ 152 trials Sub-types →
- Lobular breast carcinoma in situ 27 trials
- Lung adenocarcinoma in situ 1 trial
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Bladder carcinoma in situ 30 trials
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Intestine carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Rectum carcinoma in situ 1 trial · 13 incl. sub-types Sub-types →
- Colon carcinoma in situ 3 trials Sub-types →
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Uterus carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Uterine cervix carcinoma in situ 15 trials
- Endometrium carcinoma in situ 1 trial
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Esophagus carcinoma in situ 13 trials
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Squamous carcinoma in situ 5 trials · 10 incl. sub-types
3 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Penis carcinoma in situ 1 trial
- Trachea carcinoma in situ 0 trials
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Skin carcinoma in situ 3 trials · 9 incl. sub-types
1 sub-type
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
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Oral cavity carcinoma in situ 5 trials
1 sub-type
- Lip carcinoma in situ 0 trials
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Stomach carcinoma in situ 4 trials
3 sub-types
- Carcinoma in situ of fundus of stomach 0 trials
- Carcinoma in situ of gastric body 0 trials
- Carcinoma in situ of gastric cardia 0 trials
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Lung carcinoma in situ 2 trials · 3 incl. sub-types
2 sub-types
- Lung adenocarcinoma in situ 1 trial
- Bronchus carcinoma in situ 0 trials
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Pharynx carcinoma in situ 0 trials · 2 incl. sub-types
3 sub-types
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Larynx carcinoma in situ 1 trial
1 sub-type
- Carcinoma in situ of epiglottis 0 trials
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Carcinoma in situ of ureter 0 trials
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Carcinoma in situ of urethra 0 trials
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Eye carcinoma in situ 0 trials
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Gall bladder carcinoma in situ 0 trials
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Kidney carcinoma in situ 0 trials
1 sub-type
- Carcinoma in situ of renal pelvis 0 trials
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Liver carcinoma in situ 0 trials
1 sub-type
- Bile duct carcinoma in situ 0 trials Sub-types →
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Nasal cavity carcinoma in situ 0 trials
Most studied deeper sub-types
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New drug combo shows promise for tough bladder cancer
Disease control CompletedThis early-phase trial tested two drugs—durvalumab and vicineum—in 15 people with high-grade non-muscle-invasive bladder cancer that had not responded to standard BCG treatment. The goal was to see if the combination is safe and can help the immune system fight the cancer. Partic…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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A smartphone app may help young cancer survivors get fitter — a trial puts it to the test
Disease control CompletedThis phase 3 trial tests whether a web-based physical activity program, including a wearable tracker and interactive app, can improve fitness and long-term health in children and adolescents who have completed cancer treatment. Participants are randomly assigned to receive either…
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Nipple-Sparing mastectomy shows promise in breast cancer trial
Disease control CompletedThis study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…
Phase 3 • Sponsor: Institut Claudius Regaud • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Engineered immune cells take on HPV cancers
Disease control CompletedThis trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Heart transplant drug may also fight skin cancer
Disease control CompletedThis study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…
Phase 3 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New light device could spot skin cancer without a scalpel
Diagnosis CompletedThis study tested a non-invasive device that uses light to classify skin lesions as healthy, actinic keratosis, or carcinoma. Researchers aimed to see if it could help doctors diagnose skin conditions more accurately without needing a biopsy. The study involved 142 adults with su…
Sponsor: Centre Hospitalier Régional Metz-Thionville • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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Pocket-Sized ultrasound could speed up breast cancer detection
Diagnosis CompletedThis study looked at whether a small, portable ultrasound device can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) breast lumps in women who had a positive clinical breast exam. Researchers tested the device on 150 women, using standard i…
Sponsor: International Agency for Research on Cancer • Aim: Diagnosis
Last updated Jun 27, 2026 12:03 UTC