IgG4-related dacryoadenitis and sialadenitis

IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis.

Also known as: Mikulicz disease, chronic dacryoadenitis and sialadenitis, Mikulicz disease (former), Mikulicz syndrome (former), Mikulicz's disease (former)

45 clinical trials for this condition and its sub-types.