Hyperkeratosis-hyperpigmentation syndrome

MONDO:0007757

Hyperkeratosis-hyperpigmentation syndrome describes a very rare hyperpigmentation of the skin characterized by tiny hyperpigmented spots mainly on skin exposed to sunlight, together with mild punctate palmoplantar papular hyperkeratosis as a major feature. There have been no further descriptions in the literature since 1993.

Also known as: hyperkeratosis-hyperpigmentation syndrome

2 clinical trials for this condition and its sub-types, 0 tagged with Hyperkeratosis-hyperpigmentation syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary skin disorder (880) ↑ Autosomal dominant disease (699) ↑ Hyperpigmentation of the skin (31)

Including sub-types (2) Tagged with Hyperkeratosis-hyperpigmentation syndrome (0)

Not yet recruiting 1 Completed 1

Can seaweed microspicules turn back the clock on aging skin?

Symptom relief Not yet recruiting

This pilot trial tests a topical cream containing patented microspicules that deliver Penghu seaweed extracts to the skin. The study will enroll healthy adults aged 40-65 with signs of facial aging or pigmentation, applying the cream to one side of the face for comparison. Resear…

Sponsor: Chung Shan Medical University • Aim: Symptom relief

Last updated Aug 21, 2026 00:00 UTC

Hyperkeratosis-hyperpigmentation syndrome

Where it sits in the disease tree

Can seaweed microspicules turn back the clock on aging skin?