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Hyper-IgM syndrome

MONDO:0003947

A primary immune deficiency disorder characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic hypermutation.

Also known as: immunodeficiency with hyper-IgM, hyperimmunoglobulin M syndrome

97 clinical trials for this condition and its sub-types.

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Sub-types

Hyper-IgM syndrome type 1 (3) Hyper-IgM syndrome type 2 (1) Hyper-IgM syndrome type 3 (1) Hyper-IgM syndrome type 5 (1) Hyper-IgM syndrome type 4 (0)

Broader categories

Disease (618) Hereditary disease (172) Hematologic disorder (160) Immune system disorder (140) Inborn error of immunity (113) Immunodeficiency disease (48) Human disease (14) Leukocyte disorder (5) B cell deficiency (4) Disease of genetic or genomic mechanism (2)

Trials to join now! 50 Not yet recruiting 8 Not yet finished but already full! 13 Completed 25 Terminated 1

Can extra care after transplant help older patients live better?

Disease control Terminated

This study tested two extra care programs—supportive palliative care and clinical management of other health issues—for older or frail patients who had a donor stem cell transplant. The goal was to see if these programs could improve quality of life and survival compared to stand…

Phase: PHASE2, PHASE3 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control

Last updated Jun 27, 2026 08:10 UTC

Hyper-IgM syndrome

Sub-types

Broader categories

Can extra care after transplant help older patients live better?