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Holoprosencephaly 4

MONDO:0007734

A rare disorder caused by mutations in the TGIF gene mapped to chromosome 18p11.3. It is characterized by semilobar holoprosencephaly, hypotelorism, and ptosis.

Also known as: HPE4, TGIF1 holoprosencephaly, holoprosencephaly 4, holoprosencephaly caused by mutation in TGIF1, holoprosencephaly type 4

10 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Nervous system disorder (217) Hereditary disease (172) Endocrine system disorder (61) Syndromic disease (24) Hereditary endocrine growth disease (23) Human disease (14) Developmental defect during embryogenesis (7) Hereditary neurological disease (5) Disease of genetic or genomic mechanism (2)
Trials to join now! 6 Not yet finished but already full! 1 Completed 3
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  • Brain scans reveal hidden links between body diseases and metabolism

    Knowledge-focused Ongoing

    This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

    Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Knowledge-focused

    Last updated Jun 27, 2026 07:52 UTC

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