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High pressure neurological syndrome

MONDO:0002570

A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and seizures. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.

5 clinical trials for this condition and its sub-types.

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Sub-types

Decompression sickness (5)

Broader categories

Disease (717) Nervous system disorder (243) Central nervous system disorder (115) Human disease (15) Disease by body system or component (0)
Not yet recruiting 2 Not yet finished but already full! 1 Completed 2
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  • New drug aims to prevent Diver's bends

    Disease control Ongoing

    This study tests whether an experimental drug called rhu-pGSN can reduce harmful inflammation caused by rapid decompression after high-pressure exposure. Thirty-six healthy, trained divers will be placed in a hyperbaric chamber to simulate a deep dive. Some will receive the drug …

    Phase 2 • Sponsor: BioAegis Therapeutics Inc. • Aim: Disease control

    Last updated Jun 27, 2026 07:55 UTC

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