Hereditary angioedema with C1Inh deficiency
MONDO:0033946Forms of hereditary angioedema that occur due to mutations in the gene for complement C1 inhibitor protein. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein.
Also known as: angioedema, hereditary, 1 and 2, angioedema, hereditary, type 1/2, C1 esterase inhibitor, deficiency of, HAE1, angioedema, hereditary, type 1, angioedema, hereditary, type 2, angioedema, hereditary, type I, angioneurotic edema, hereditary
34 clinical trials for this condition and its sub-types, 14 tagged with Hereditary angioedema with C1Inh deficiency itself.
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Sub-types of Hereditary angioedema with C1Inh deficiency
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Hereditary angioedema type 1 26 trials
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Hereditary angioedema type 2 26 trials
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CRISPR therapy takes on rare swelling disorder
Disease control OngoingThis phase 3 trial tests a one-time gene editing treatment called NTLA-2002 for people with hereditary angioedema (HAE), a rare genetic condition causing sudden, painful swelling attacks. About 80 participants will receive either the treatment or a placebo. The goal is to see if …
Phase 3 • Sponsor: Intellia Therapeutics • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New pill could stop dangerous swelling attacks in hereditary angioedema
Symptom relief By invitation onlyThis study tests a pill called deucrictibant for quickly treating swelling attacks in people with hereditary angioedema (HAE), including life-threatening throat swelling. About 150 adults who have had HAE attacks before will take the drug as needed and be monitored for safety and…
Phase 2/3 • Sponsor: Pharvaris Netherlands B.V. • Aim: Symptom relief
Last updated Jul 23, 2026 00:00 UTC