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Growth hormone insensitivity syndrome

MONDO:0015892

Growth hormone insensitivity syndrome (GHIS) is a group of diseases characterized by marked short stature associated with normal or elevated growth hormone (GH) concentrations, which fail to respond to exogenous GH administration. GHIS comprises growth delay due to IGF-1 deficiency, growth delay due to IGF-1 resistance, Laron syndrome, short stature due to STAT5b deficiency and primary acid-labile subunit (ALS) deficiency.

Also known as: GHIS, Growth hormone insensitivity syndromes, short stature due to a defect in growth hormone receptor or post-receptor pathway

12 clinical trials for this condition and its sub-types.

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Sub-types

Growth delay due to insulin-like growth factor I resistance (4) Growth delay due to insulin-like growth factor type 1 deficiency (1) Growth hormone insensitivity with immune dysregulation 1, autosomal recessive (1) Growth hormone insensitivity syndrome with immune dysregulation (0) Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant (0) Laron syndrome (0) Short stature due to partial GHR deficiency (0) Short stature due to primary acid-labile subunit deficiency (0)

Broader categories

Disease (618) Endocrine system disorder (61) Syndromic disease (24) Hereditary endocrine growth disease (23) Human disease (14) Disease by body system or component (0)
Trials to join now! 8 Not yet recruiting 1 Not yet finished but already full! 2 Completed 1
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