Familial bicuspid aortic valve
MONDO:0007194A rare, genetic, aortic malformation defined as a presence of abnormal two-leaflet aortic valve in at least 2 first-degree relatives. It is frequently asymptomatic or may be associated with progressive aortic valve disease (aortic regurgitation and/or aortic stenosis, typically due to valve calcification) and a concomitant aortopathy (i.e. aortic dilation, aortic aneurysm and/or dissection).
Also known as: familial BAV, AOVD1, aortic valve disease 1, aortic valve disease type 1
76 clinical trials for this condition and its sub-types, 6 tagged with Familial bicuspid aortic valve itself.
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Sub-types of Familial bicuspid aortic valve
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Aortic valve disease 1 16 trials
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Aortic valve disease 2 12 trials
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Aortic valve disease 3 0 trials
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Less invasive heart valve replacement put to the test against Open-Heart surgery
Disease control Recruiting nowThis study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …
Sponsor: Cedars-Sinai Medical Center • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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New imaging study peers inside rare heart valve condition
Knowledge-focused Recruiting nowThis study will follow 60 adults with a bicuspid aortic valve (a heart valve with two flaps instead of three) for five years. Each year, participants will get a special 4D CT scan to take detailed measurements of the valve's shape and movement. The goal is to learn more about how…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC