Familial Alzheimer disease
MONDO:0100087A degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. About 25% of all Alzheimer disease is familial (more than 2 people in a family have AD). When Alzheimer disease begins before 60 or 65 years of age (early-onset AD) about 60% of the cases are familial (also known as Early-onset familial AD). These cases appear to be inherited in an autosomal dominant manner.
Also known as: Alzheimer disease, familial, FAD, GARD:0000632
58 clinical trials for this condition and its sub-types, 13 tagged with Familial Alzheimer disease itself.
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Sub-types of Familial Alzheimer disease
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Early-onset autosomal dominant Alzheimer disease 31 trials · 37 incl. sub-types
14 sub-types
- Alzheimer disease 3 5 trials
- Alzheimer disease type 1 4 trials
- Alzheimer disease 4 3 trials
- Alzheimer disease 10 1 trial
- Alzheimer disease 11 1 trial
- Alzheimer disease 12 1 trial
- Alzheimer disease 13 1 trial
- Alzheimer disease 14 1 trial
- Alzheimer disease 5 1 trial
- Alzheimer disease 6 1 trial
- Alzheimer disease 7 1 trial
- Alzheimer disease 8 1 trial
- Alzheimer disease without neurofibrillary tangles 1 trial
- Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology 0 trials
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Alzheimer disease 2 11 trials
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Could a new pill break up Alzheimer's brain clumps?
Disease control CompletedThis study tests a new drug called PRI-002 in 304 people with mild memory problems or early Alzheimer's. The drug aims to break apart harmful protein clumps in the brain that are linked to Alzheimer's. Researchers want to see if it is safe and can slow down memory and thinking de…
Phase 2 • Sponsor: PRInnovation GmbH • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Hunt for hidden genes behind early Alzheimer's
Knowledge-focused CompletedThis study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC