Please sign in to follow a disease.
Craniosynostosis
MONDO:0015469Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome.
Also known as: craniosynostosis syndrome, premature closure of cranial sutures, CSO
39 clinical trials for this condition and its sub-types, 17 tagged with Craniosynostosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Craniosynostosis
-
Syndromic craniosynostosis 1 trial · 22 incl. sub-types
40 sub-types
- Acrocephalosyndactyly 0 trials · 13 incl. sub-types Sub-types →
- Crouzon syndrome-acanthosis nigricans syndrome 4 trials
- Antley-Bixler syndrome 2 trials Sub-types →
- Muenke syndrome 2 trials
- Crouzon syndrome 1 trial Sub-types →
- Shprintzen-Goldberg syndrome 1 trial
- Pseudoaminopterin syndrome 1 trial
- Baller-Gerold syndrome 0 trials
- Beare-Stevenson cutis gyrata syndrome 0 trials
- C syndrome 0 trials
- Curry-Jones syndrome 0 trials
- Hunter-McAlpine craniosynostosis 0 trials
- Lowry-MacLean syndrome 0 trials
- Summitt syndrome 0 trials
- TCF12-related craniosynostosis 0 trials
- Weiss-Kruszka syndrome 0 trials
- X-linked intellectual disability-plagiocephaly syndrome 0 trials
- Acrocephalopolydactyly 0 trials
- Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome 0 trials
- Cardiocranial syndrome, Pfeiffer type 0 trials
- Cloverleaf skull-asphyxiating thoracic dysplasia syndrome 0 trials
- Cloverleaf skull-multiple congenital anomalies syndrome 0 trials
- Cranioectodermal dysplasia 0 trials Sub-types →
- Craniomicromelic syndrome 0 trials
- Craniosynostosis 2 0 trials
- Craniosynostosis 4 0 trials
- Craniosynostosis and dental anomalies 0 trials
- Craniosynostosis, Herrmann-Opitz type 0 trials
- Craniosynostosis, Philadelphia type 0 trials
- Craniosynostosis-anal anomalies-porokeratosis syndrome 0 trials
- Craniosynostosis-cataract syndrome 0 trials
- Craniosynostosis-fibular aplasia syndrome 0 trials
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome 0 trials
- Craniosynostosis-intracranial calcifications syndrome 0 trials
- Craniotelencephalic dysplasia 0 trials
- Familial scaphocephaly syndrome 0 trials Sub-types →
- Holoprosencephaly-craniosynostosis syndrome 0 trials
- Lethal occipital encephalocele-skeletal dysplasia syndrome 0 trials
- Osteosclerosis-developmental delay-craniosynostosis syndrome 0 trials
- Trigonocephaly-broad thumbs syndrome 0 trials
-
Isolated craniosynostosis 1 trial · 3 incl. sub-types
4 sub-types
- Isolated oxycephaly 0 trials · 2 incl. sub-types Sub-types →
- Isolated cloverleaf skull syndrome 0 trials
- Isolated trigonocephaly 0 trials Sub-types →
- Non-syndromic unisutural craniosynostosis 0 trials
-
Craniosynostosis syndrome, autosomal recessive 0 trials · 2 incl. sub-types
2 sub-types
- Antley-Bixler syndrome 2 trials Sub-types →
- Cranioectodermal dysplasia 0 trials Sub-types →
-
Iida Kannari syndrome 0 trials
-
Craniosynostosis Fontaine type 0 trials
-
Craniosynostosis autosomal dominant 0 trials
-
Craniosynostosis contractures cleft 0 trials
-
Craniosynostosis with ectopia lentis 0 trials
-
Craniosynostosis, Adelaide type 0 trials
-
Mehta lewis patton syndrome 0 trials
Most studied deeper sub-types
-
Nano-ink gel could replace repeated skull surgeries for kids with rare genetic disorders
Disease control Recruiting nowThis early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
-
Can a helmet or simple repositioning reshape an Infant's head?
Disease control Recruiting nowThis trial tests two ways to correct flat head syndrome in infants: caregiver-led repositioning and a custom-fit helmet. Researchers will measure head shape changes in treated infants and compare them with a group of typically developing infants. Infants with torticollis will als…
Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
-
Can some children with a pointed skull skip major surgery?
Knowledge-focused Recruiting nowTrigonocephaly is a condition where a baby's skull fuses too early along the forehead, giving the head a pointed shape. Doctors often operate to relieve pressure on the growing brain, but some children may do just as well without surgery. This study follows children aged 0 to 8 w…
Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
-
Fingertip sensor may help surgeons manage bleeding in infant skull operations
Knowledge-focused Recruiting nowThis study looks at whether a simple, non-invasive fingertip sensor (called pleth variability index, or PVI) can help doctors track blood pressure and fluid needs during skull surgery in children aged 0 to 6 years with craniosynostosis. The researchers will compare PVI readings w…
Sponsor: Muzaffer GENCER • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
-
Bone cell study explores direct effects of rickets drug
Knowledge-focused Recruiting nowThis study looks at bone cells from children having surgery for craniosynostosis (early skull bone fusion). Researchers want to see how burosumab and vitamin D directly affect these cells, especially in children with a rare bone disease called hypophosphatemic rickets. The goal i…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
-
Study reveals eye issues in skull condition
Knowledge-focused Recruiting nowThis study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
-
New monitoring method may improve safety for infant skull surgery
Knowledge-focused Recruiting nowThis study looks at 30 infants (3-8 months old) having surgery for craniosynostosis, a condition where skull bones fuse too early. Researchers want to see if a new monitoring method (PRAM) can better track blood pressure and fluid loss than standard monitors. The goal is to impro…
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC